Ocular Health Study
Responsible HRP Element:
Human Health Countermeasures
|Space Medicine Medical Operations/NASA JSC
Active - Task currently funded
The International Space Station (ISS) Ocular Health Study aims to systematically gather physiological data to characterize the Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations on crewmembers assigned to a 6 month ISS increment. The data collected will mirror Medical Requirements Integration Documents (MRID) requirements and testing performed during annual medical exams. The frequency of in-flight and postflight testing will be increased to more accurately assess changes that occur in the visual, vascular, and central nervous systems upon exposure to microgravity and induction of fluid shifting. Monitoring in-flight changes, in addition to postflight recovery, is the main focus of this protocol. A data sharing plan with Medical Operations will reduce redundancy of data acquisition. Preflight, in-flight and postflight measures include: tonometry, ocular ultrasound, fundoscopy, and visual acuity; while magnetic resonance imaging (MRI), optical coherence tomography (OCT), and bio-microscopy will be captured preflight and postflight exclusively. Two additional, non-MRID measures, blood pressure and cardiac output, will be collected preflight, in-flight and postflight to assess vascular compliance. Data collection will begin one year prior to flight, continue in-flight approximately every 30 days, and through to one year postflight. In circumstances where abnormalities may persist beyond one year, postflight data will continue to be collected, but as per the MRID requirements (MedB 1.10) and Visual Impairment/Intracranial Pressure (VIIP) clinical practice guidelines.