Short Title:
Ocular Health Study
Responsible HRP Element:
Human Health Countermeasures
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Supporting Org(s):
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| Space Medicine Medical Operations/NASA JSC |
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Funding Status:
Active - Task currently funded
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Procurement Mechanism(s):
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Aims:
The International Space Station (ISS) Ocular Health Study aims to systematically gather physiological data to characterize the Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations on crewmembers assigned to a 6 month ISS increment. The data collected will mirror Medical Requirements Integration Documents (MRID) requirements and testing performed during annual medical exams. The frequency of in-flight and postflight testing will be increased to more accurately assess changes that occur in the visual, vascular, and central nervous systems upon exposure to microgravity and induction of fluid shifting. Monitoring in-flight changes, in addition to postflight recovery, is the main focus of this protocol. A data sharing plan with Medical Operations will reduce redundancy of data acquisition. Preflight, in-flight and postflight measures include: tonometry, ocular ultrasound, fundoscopy, and visual acuity; while magnetic resonance imaging (MRI), optical coherence tomography (OCT), and bio-microscopy will be captured preflight and postflight exclusively. Two additional, non-MRID measures, blood pressure and cardiac output, will be collected preflight, in-flight and postflight to assess vascular compliance. Data collection will begin one year prior to flight, continue in-flight approximately every 30 days, and through to one year postflight. In circumstances where abnormalities may persist beyond one year, postflight data will continue to be collected, but as per the MRID requirements (MedB 1.10) and Visual Impairment/Intracranial Pressure (VIIP) clinical practice guidelines.
Integration/Unique Aspects:
None
Flight Resources
| Number of Subjects
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12
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| When are operations required?
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Pre/In/Post
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| When is an approved proposal expected?
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1/2/2012
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Frequency and type of in-flight sessions:
Monthly
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Type of in-flight sessions:
Visual exam including fundoscopy, tonometry, and ultrasound.
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Type of in-flight sample collection:
None
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Hardware/Software Requirements:
Utilizes existing hdw & s/w.
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BDC Requirements:
Cardiovascular ultrasound and blood pressure in conjunction with current MRID testing.
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Category:
Risk Characterization/Quantification
Subcategory:
Evidence
Description:
A final report describing the time course of visual changes during a 6-month ISS mission will be delivered. This information will be used to develop future research goals.
Customer:
HHC
Is there a signed Customer-Supplier Agreement?
No
Delivery Milestone:
9/30/2016