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NSCOR: Mechanisms of HZE Damage and Repair in Human Epithelial Cells (Completed)

Task Book: Entry
Principal Investigator: Barcellos-Hoff, Mary

Short Title: HZE Epithelial

Responsible HRP Element: Space Radiation

Supporting Org(s):

NASA/Fundamental Space Biology

Funding Status: Completed - Task has been completed

Procurement Mechanism(s):

NASA Specialized Center of Research

Aims:
The intent of this 5-year project NSCOR at Lawrence Berkeley National Laboratory Life Sciences Division is to provide a comprehensive examination of HZE effects from the initial damage, to early cellular HMEC responses, to persistent functional precursors of carcinogenesis.

Integration/Unique Aspects:

Resources (None Listed)

Deliverables (1)

Mappings

Risk of Radiation Carcinogenesis

Cancer 01: How can experimental models of tumor development for the major tissues (lung, colon, stomach, breast, liver, and leukemias) be developed to represent the major processes in radiation carcinogenesis and extrapolated to human risk projections?

Cancer 03: How can models of cancer risk be applied to reduce the uncertainties in radiation quality effects from SPE's and GCR?

Cancer 05: How can models of cancer risk be applied to reduce the uncertainties in individual radiation sensitivity including genetic and epigenetic factors from SPE and GCR?

Cancer 06: How can models of cancer risk be applied to reduce the uncertainties in the age and gender dependence of cancer risks from SPE's and GCR?

Cancer 07: How can systems biology approaches be used to integrate research on the molecular, cellular, and tissue mechanisms of radiation damage to improve the prediction of the risk of cancer and to evaluate the effectiveness of CM's? How can epidemiology data and scaling factors support this approach?

NSCOR: Mechanisms of HZE Damage and Repair in Human Epithelial Cells

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Schedules (1)

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Common Item(s)
	Risk of Radiation Carcinogenesis
	Cancer 03: How can models of cancer risk be applied to reduce the uncertainties in radiation quality effects from SPE's and GCR?
	Cancer 05: How can models of cancer risk be applied to reduce the uncertainties in individual radiation sensitivity including genetic and epigenetic factors from SPE and GCR?
	Cancer 06: How can models of cancer risk be applied to reduce the uncertainties in the age and gender dependence of cancer risks from SPE's and GCR?
	Cancer 07: How can systems biology approaches be used to integrate research on the molecular, cellular, and tissue mechanisms of radiation damage to improve the prediction of the risk of cancer and to evaluate the effectiveness of CM's? How can epidemiology data and scaling factors support this approach?