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SD/Development of in-flight diagnostic OCT

Task Book: Entry Unavailable
Principal Investigator: N/A

Short Title: In-flight OCT

Responsible HRP Element: Human Health Countermeasures

Supporting Org(s):

Space Medicine Medical Operations/NASA JSC

Funding Status: Planned - Task expected to be within budget

Procurement Mechanism(s):

Direct Contract

Aims:
To develop and certify Optical Coherence Tomography (OCT) measurement device for flight evaluations of optical health. This work is expected to be funded by the ISS Program Office and developed by Space Medicine.

Integration/Unique Aspects:
None

Resources (None Listed)

Deliverables (1)

Category: Technology
Subcategory: Clinical Care/Medical Informatics

Description:
Flight ready OCT hardware.

Customer: Space Medicine
Is there a signed Customer-Supplier Agreement? No

Delivery Milestone: 9/30/2015

Mappings

Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

SD/Development of in-flight diagnostic OCT

Related Tasks (52)

Bracelet Investigation

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Fluid distribution animal study: bone loss, venous pressure, cerebral blood flow, lower limb arteriole atrophy

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Hindlimb suspension (HS) as an analog model of ocular alterations associated with cephalad fluid shifts: resveratrol as a countermeasure

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Pilot study to evaluate a novel non-invasive technology to estimate peripheral and central venous pressure

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

rVisual Impairment and Intracranial Pressure Project Data Mining

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Phase I: SD-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Phase II: D-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals and Pseudotumor/Increased Intracranial Hypertension Patients

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Prospective Observational Study of Ocular Health in ISS Crews

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

A data mining project to identify cardiovascular related factors that may contribute to changes in visual acuity within the astronaut corps

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Are Medications Involved in Vision and Intracranial Pressure Changes Seen in Spaceflight?

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Flight-Vascular Function in the Head/Neck

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

SD/On-going VIIP Hardware Techwatch

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

SD/Development of in-flight fundoscopy

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

SD/Fundoscopy Trade Study

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

SD/Diagnostic OCT Trade Study

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

ICP Tech Search (Innocentive, Yet To Come)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

Effects of Microgravity on Intracranial Pressure

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Analysis of a Clinical Database as a Means to Validate Non-invasive Assessment of Intracranial Pressure Using the Cerebral and Cochlear Fluid Pressure (CCFP) Analyzer

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

SD/Upgrade Visual Acuity Software and In-flight Tonometer

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

Non-invasive ICP device purchase & evaluation

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

Flight validation - Combination Countermeasure for VIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Ground - Combination Countermeasure for VIIP (Drug + Exercise and/or Mechanical CM)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Ground - Aerobic Exercise Countermeasure for VIIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Drug Countermeasure Flight Validation – Acetazolamide, manipulation of AQP1 and AQP4, Atrial Nateuretic Peptide to decrease ICP, drug to decrease CSF production

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Ground/Bedrest Drug Countermeasure for VIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Head-down tilt as a model for intracranial and intraocular pressures, and retinal changes during spaceflight

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Flight - Contributions of CO2, resistive exercise, and sodium to the VIIP syndrome – effect on cerebrovascular dilation and ICP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Bedrest – Contributions of CO2, resistive exercise, and sodium to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Data mining – Contributions of CO2 to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Pre & Postflight MRV review (central venous congestion)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Evaluation of increased CSF dynamics (production/absorption) during spaceflight

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Pre and postflight measurement of cerebrospinal fluid (CSF) dynamics (production/absorption)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Biomarker for identification of increased ICP - Flight Validation

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Biomarker for identification of increased ICP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Validation of in-flight non-invasive ICP as compared to pre and post lumbar puncture

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Evaluation of spaceflight alterations in neurohumoral control and vascular function changes towards VIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

SD/In-flight monitoring of visual health (MRID)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Ocular structure, biomechanics and translaminar pressure gradients in relation to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Data Mining – Ocular structure and biomechanics in relation to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Visual Impairment Intracranial Pressure Risk: Occupational Surveillance Data Mining

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations Evidence Report

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Microgravity Associated Compartmental Equilibration (MACE)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Fluid Distribution before, during and after Prolonged Space Flight

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Human Cerebral Vascular Autoregulation and Venous Outflow in Response to Microgravity-Induced Cephalad Fluid Redistribution

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Non-Invasive Monitoring of Intracranial Pressure (ICP) with Volumetric Ophthalmic Ultrasound

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

Non-invasive ICP Flight Hardware Development

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP3: Identify in-flight diagnostic tools to measure changes in ocular structure and function and/or intracranial pressure related to the VIIP syndrome. (hardware/techwatch)

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Schedules (1)

This task can be found in the following Risk schedules.

VIIP Schedule

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