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Biomarker for identification of increased ICP

Task Book: Entry Unavailable
Principal Investigator: TBD

Short Title: Biomarker ICP

Responsible HRP Element: Human Health Countermeasures

Supporting Org(s):

Funding Status: Unfunded - Task not within current budget

Procurement Mechanism(s):

Aims:
This study will evaluate currently identified biomarkers for the detection of increased intracranial pressure in a ground population.

Integration/Unique Aspects:
None

Resources (Ground Analog)

Ground Analog Resources

Platform	Validated VIIP Analog
Number of Subjects	12
Can data from subjects be collected over multiple missions/campaigns?	Yes
Fiscal Year	2014
Days per subject	0
Top Level Requirements: Ground analog testing

Deliverables (1)

Category: Risk Characterization/Quantification
Subcategory: Evidence

Description:
A potential biomarker to identify raised ICP for flight validation.

Customer: HHC
Is there a signed Customer-Supplier Agreement? No

Delivery Milestone: 9/30/2016

Mappings

Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Biomarker for identification of increased ICP

Related Tasks (52)

Bracelet Investigation

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	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Fluid distribution animal study: bone loss, venous pressure, cerebral blood flow, lower limb arteriole atrophy

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R

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	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Hindlimb suspension (HS) as an analog model of ocular alterations associated with cephalad fluid shifts: resveratrol as a countermeasure

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	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

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	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Pilot study to evaluate a novel non-invasive technology to estimate peripheral and central venous pressure

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

rVisual Impairment and Intracranial Pressure Project Data Mining

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Phase I: SD-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Phase II: D-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals and Pseudotumor/Increased Intracranial Hypertension Patients

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Prospective Observational Study of Ocular Health in ISS Crews

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

A data mining project to identify cardiovascular related factors that may contribute to changes in visual acuity within the astronaut corps

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Are Medications Involved in Vision and Intracranial Pressure Changes Seen in Spaceflight?

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Flight-Vascular Function in the Head/Neck

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

SD/On-going VIIP Hardware Techwatch

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

SD/Development of in-flight fundoscopy

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

SD/Fundoscopy Trade Study

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

SD/Development of in-flight diagnostic OCT

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

SD/Diagnostic OCT Trade Study

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

ICP Tech Search (Innocentive, Yet To Come)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Effects of Microgravity on Intracranial Pressure

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Analysis of a Clinical Database as a Means to Validate Non-invasive Assessment of Intracranial Pressure Using the Cerebral and Cochlear Fluid Pressure (CCFP) Analyzer

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

SD/Upgrade Visual Acuity Software and In-flight Tonometer

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Non-invasive ICP device purchase & evaluation

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Flight validation - Combination Countermeasure for VIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Ground - Combination Countermeasure for VIIP (Drug + Exercise and/or Mechanical CM)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Ground - Aerobic Exercise Countermeasure for VIIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Drug Countermeasure Flight Validation – Acetazolamide, manipulation of AQP1 and AQP4, Atrial Nateuretic Peptide to decrease ICP, drug to decrease CSF production

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Ground/Bedrest Drug Countermeasure for VIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Head-down tilt as a model for intracranial and intraocular pressures, and retinal changes during spaceflight

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Flight - Contributions of CO2, resistive exercise, and sodium to the VIIP syndrome – effect on cerebrovascular dilation and ICP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Bedrest – Contributions of CO2, resistive exercise, and sodium to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Data mining – Contributions of CO2 to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Pre & Postflight MRV review (central venous congestion)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Evaluation of increased CSF dynamics (production/absorption) during spaceflight

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Pre and postflight measurement of cerebrospinal fluid (CSF) dynamics (production/absorption)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Biomarker for identification of increased ICP - Flight Validation

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Validation of in-flight non-invasive ICP as compared to pre and post lumbar puncture

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Evaluation of spaceflight alterations in neurohumoral control and vascular function changes towards VIIP

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

SD/In-flight monitoring of visual health (MRID)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Ocular structure, biomechanics and translaminar pressure gradients in relation to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Data Mining – Ocular structure and biomechanics in relation to the VIIP syndrome

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Visual Impairment Intracranial Pressure Risk: Occupational Surveillance Data Mining

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations Evidence Report

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Microgravity Associated Compartmental Equilibration (MACE)

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Fluid Distribution before, during and after Prolonged Space Flight

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Human Cerebral Vascular Autoregulation and Venous Outflow in Response to Microgravity-Induced Cephalad Fluid Redistribution

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations
	VIIP1: What is the etiology of visual acuity and ocular structural and functional changes seen in-flight and postflight?

Non-Invasive Monitoring of Intracranial Pressure (ICP) with Volumetric Ophthalmic Ultrasound

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

Non-invasive ICP Flight Hardware Development

Common Item(s)
	Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations

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Schedules (1)

This task can be found in the following Risk schedules.

VIIP Schedule

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