Short Title:
Integrated Fluid volume- Hargens
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Task currently funded
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Procurement Mechanism(s):
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| NASA Research Announcement |
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Aims:
We have five specific aims to test our hypothesis that prolonged-microgravity,
head-ward volume and pressure shifts are responsible for elevating intracranial pressure (ICP) and producing deficits in crewmembers’ vision:
1) To measure periocular fluid volumes, intraocular pressure (IOP), and upper-body
compartment volumes before, during and after prolonged microgravity
2) To quantify jugular and parajugular vein dimensions, valve competency, blood flow using ultrasound before, during and after prolonged microgravity exposure
3) To measure ventricular and cerebrospinal volumes using ultrasound before, during and after prolonged microgravity exposure,
4) To image the retina to detect retinal venous distension in space, and
5) To evaluate ICP, IOP, and select ocular structures and functions while applying a purely mechanical countermeasure of low-level, lower body negative pressure (LBNP) to counteract the head-ward fluid shift in space.
Integration/Unique Aspects:
This study is planned to be integrated with two other flight proposals from the 2011 NRA: M. Stenger and S. Dulchavsky.
Flight Resources
| Number of Subjects
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12
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| When are operations required?
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Pre/In/Post
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| When is an approved proposal expected?
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11/1/2012
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Frequency and type of in-flight sessions:
early, mid, late
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Type of in-flight sessions:
ultrasound, intervention response
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Type of in-flight sample collection:
data collection
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Hardware/Software Requirements:
TBD
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BDC Requirements:
ultrasound
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Category:
Countermeasures
Subcategory:
Prototype Hardware, Pharmaceutical, Nutritional Supplement
Description:
A final report detailing the changes in fluid shift during space flight and potential countermeasure testing.
Customer:
HHC
Is there a signed Customer-Supplier Agreement?
No
Delivery Milestone:
9/29/2017