HRR - Task

Human Research Roadmap HRP Exploration Data

- CNS – 2
  - CNS
- CNS – 6
  - CNS

Mechanisms of Low Dose HZE Alteration of Neuronal-Astrocytic Coupling: The Role of Purinergic Receptors and Calcium Signaling

Task Book: Entry Unavailable
Principal Investigator: Sanchez, Martha for Green, Lora

Short Title: Astrocyte Alteration

Responsible HRP Element: Space Radiation

Supporting Org(s):

Funding Status: Active - Task currently funded

Procurement Mechanism(s):

NASA Research Announcement

Earmark

Aims:

Integration/Unique Aspects:

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization/Quantification
Subcategory: Evidence

Description:
Annual and Final Reports

Customer:
Is there a signed Customer-Supplier Agreement? No

Delivery Milestone: 9/30/2013

Mappings

Risk of Acute and Late Central Nervous System Effects from Radiation Exposure

CNS – 2: Is there a significant probability that space radiation exposures would lead to long-term or late degenerative CNS risks if so what are the mechanisms of change?

CNS – 6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human date be used to estimate late CNS risks to astronauts from GCR and SPE?

Mechanisms of Low Dose HZE Alteration of Neuronal-Astrocytic Coupling: The Role of Purinergic Receptors and Calcium Signaling

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Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

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The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis

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Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

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Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

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Long term CNS effects of space radiation

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Common Item(s)
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Common Item(s)
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	CNS – 6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human date be used to estimate late CNS risks to astronauts from GCR and SPE?

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Common Item(s)
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	CNS – 2: Is there a significant probability that space radiation exposures would lead to long-term or late degenerative CNS risks if so what are the mechanisms of change?

Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells

Common Item(s)
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HZE Radiation Effects On Neuroinflammation: Role Of Cox-2

Common Item(s)
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	CNS – 2: Is there a significant probability that space radiation exposures would lead to long-term or late degenerative CNS risks if so what are the mechanisms of change?

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Schedules (1)

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CNS Schedule

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