Responsible HRP Element:
Completed - Task completed and produced a deliverable
- We will quantify apoptosis, proliferation and differentiation, as early hallmarks of cancer, in 3D epithelial tissue models of skin, a tissues in which radiation is known to cause cancer.
- A novel aspect of our studies is to test the hypothesis that radiation can alter the ability of dendritic cells to participate in immune surveillance and that radiation-induced persistent oxidative stress is part of the underlying mechanism.
- Studies comparing radiation and bystander effects in normal, pre-cancerous and neoplastic epithelial cells will be conducted. An important component of anti-cancer processes in epithelial tissues is the immune system, including dendritic cells which are critically involved in immune surveillance against cancer.
- We will quantify apoptosis, proliferation and differentiation, as early hallmarks of cancer, in 3D epithelial tissue models of colon, a tissue in which radiation is known to cause cancer.