CNS Late I
Responsible HRP Element:
Planned-Unfunded - Task not within current budget
Determine the probability that space radiation exposure would lead to long term adverse outcomes in CNS function and structure. Identify key events and potential biomarkers in adverse outcome pathways and their associations with acute changes and clinically important late degenerative disorders such as Alzheimer’s and Parkinson’s diseases as well as depression and anxiety disorders. Identify reliable markers for individual predisposition or elevated susceptibility to radiation-induced adverse changes. Determine the dependence of radiation-induced late changes on charged particle types and dose rates estimated for design reference missions.
Integration:/Unique Aspects: Inform/prioritize behavioral and cognitive outcomes using input from BHP element as required.