Planned-Funded - Task expected to be within budget
Aim 1: Validate surrogate endpoint biomarkers, including standard of care clinical markers, for monitoring space radiation induced late cardiovascular disease and late CNS diseases and for use in risk assessment model development and evaluation of protective countermeasures.
Aim 2: Evaluate and identify cross-risk common pathway targets for countermeasure identification.
Aim 3: Identify candidate radioprotective agents for late cardiovascular and CNS diseases.
Aim 4: Evaluate exercise as protective mechanisms for late cardiovascular and CNS diseases.
Aim 5: Evaluate efficacy of candidate agents, for prevention of late cardiovascular and CNS diseases using appropriate animal models.