Planned-Funded - Task expected to be within budget
Aim 1 (Cancer): Obtain Evidence using mixed field chronic GCR simulation that supports improvement in accuracy of dose and dose-rate effectiveness factor (DDREF) estimates and information on whether risk is linear or additive over mixed high and low LET.
Aim 2 (Cancer): Determine tissue specific mixed field RBE values for tumorigenesis and other cancer endpoints for major at risk tissues.
Aim 3 (Cancer): Integrated omics evaluation of HZE cancer processes leading to cancer development.
Aim 4 (Cancer): Perform molecular characterization of tumors for major at risk tissues.
Aim 5 (Cancer): Perform preliminary countermeasure evaluation using potential common cancer pathway targets. (e.g. inflammation)
Cancer Focused: Tissue Specific RBE for major at risk tissues & dose rate effects (Life Span Study)