Planned-Unfunded - Task not within current budget
Aim 1: Research to uncover determinants of information on individual susceptibility to space radiation induced cancers that will form the basis for individualized risk assessments and countermeasures. This may include studies to understand the contribution of genes controlling sensitivity to radiation damage, known cancer susceptibility genes, as well as studies to determine unique sensitivities specific for heavy ion induced cancers.
Aim 2: Research to quantify and describe the biological basis for the effects of sex on cancer risk from space radiation exposure.
Aim 3: Research to understand if the tissues at risk for cancer development from low-LET radiation exposure observed in human epidemiology data are reflective of those observed in animal studies with heavy ions; and research to characterize the histological differences and possible mechanistic basis for enhancement in aggressive phenotype (decreased latency, increased frequency of occurrence, accelerated progression, enhanced metastasis) observed in HZE particle versus terrestrial radiation induced cancers.
Aim 4: Research to identify biomarkers that can be used to identify and characterize individual susceptibility to space radiation and to monitor the development of adverse outcomes.
Aim 5: Research that seeks to leverage on the rapidly accumulating genomic and molecular knowledge on human cancers in order to facilitate extrapolation of results obtained in animal models to the human condition.
Aim 6: Evaluate potential for synergistic effects of other spaceflight factors.