Planned-Funded - Task expected to be within budget
Aim 1 (Acute CNS): Continue Risk Characterization - Quantify the spectrum and dose responses for acute (mission timescale) functional CNS changes directly relatable to mission operations (standard measures).
Aim 2 (Acute CNS): Define adverse outcome pathways associated with functional CNS changes (mission timescale).
Aim 3 (Acute CNS): Examination of predictive/critical measures and biomarkers.
Aim 4 (Acute CNS): Determine potential synergistic effects from other spaceflight stressors e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other.
Aim 5 (Late CNS): Risk characterization - late evaluation of behavioral changes or degenerative neurological disease associated with GCR exposure.