Planned-Funded - Task expected to be within budget
Aim 1: (Late CNS) Examine dose thresholds, dose-rate dependence and mixed field effects for late behavioral and neurodegenerative CNS diseases from space radiation.
Aim 2: (Late CNS) Define adverse outcome pathways and associated biomarkers for late CNS neurodegeneration (post mission).
Aim 3: (CVD-DGN) Determine impact of dose-rate and mixed field exposure on disease latency and progression.
Aim 4: CVD-DGN) Determine surrogate endpoints (including intermediate cardiovascular risk parameters and related biomarkers) for detection and monitoring of radiation induced cardiovascular diseases.
Aim 5: (Acute CNS): Validate predictive/critical measures and biomarkers using chronic mixed field.
CVD/CNS Focused: Combine these to a focus on certain factors such as the apoE4 allele which occur at high frequency in populations and is predisposing to both CVD, cerebrovascular disease and late neurodegeneration.
Identification of Adverse Outcome Pathways - Supports 2025 Risk Modeling NSCOR