Human Research Program Architecture
To the extent that research can address human health and performance risks, the Human Research Program (HRP) provides essential countermeasures and technologies in order to enable human space exploration. The HRP utilizes the Integrated Research Plan (IRP), a compilation of individual risk research plans, to address these risks which are assigned to specific Elements within the program.

The IRP was baselined as HRP-47065, Human Research Program Integrated Research Plan, in 2008 and is revised as required. In 2010, the technical content of the IRP (formerly Appendix A) transitioned to a web-based format contained in the Human Research Roadmap (HRR). The introduction and overview of each risk in the IRP continues to be maintained in the document

The IRP describes the approach, and research and technology development (R&TD) activities intended to mitigate the risks of human space exploration. The risks-gaps-tasks-deliverables detail in the IRP is required to ensure completeness in addressing the risks. The planned schedule to mitigate each risk is then captured in a Path to Risk Reduction (PRR) timeline for a specific Design Reference Mission (DRM). This timeline portrays critical work planned to meet significant risk milestones associated with improvements in Likelihood and Consequence (LxC) risk ratings (transitioning from red to yellow to green). While the Human System Risk Board (HSRB) has several DRMs on which to evaluate the risks, the HRP has developed PRRs for only the planetary DRM at this time.

The HRP utilizes various research platforms to conduct research. Ground research occurs in laboratories and analogs that mimic a portion of the spaceflight environment. In addition, the International Space Station (ISS) is used to conduct research requiring the unique environment of space and serves as an analog for long-duration planetary missions. Spaceflight data primarily identify and/or quantify physiological and behavioral changes to the human system under microgravity conditions and can validate potential countermeasures. The use of the ISS platform is critical to obtaining the required knowledge to build products to support longer and more challenging missions.

The HRP IRP content captured in the HRR is organized according to the following management architecture:


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In the HRR, the user will be able to download and view risk Evidence Reports; review the IRP's risk, gap, task and deliverable information; and understand the cross-integration of gaps across multiple risks, and tasks across multiple gaps.

Reviews of the accumulated evidence from medical records, spaceflight operations and research findings are compiled into the risk Evidence Reports. The individual risk reports make important data accessible and available for periodic review. This evidence helps the HSRB identify the most significant human risks in space exploration, a subset of which comprises the risk research portfolio of the HRP. It also provides the basis for identifying gaps and tasks in the IRP. As research work progresses, new evidence, along with various deliverables, are generated and contribute to the body of evidence that informs the progress of risk reduction.

Human spaceflight risks include physiological and performance effects from the hazards of spaceflight, such as altered gravity, radiation, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. Risks and Concerns in the HRP research portfolio are identified by the HSRB as those for which research activity is a major component of the mitigation strategies, and are assigned to an Element within the HRP to quantify, mitigate, or monitor.

The HSRB uses the following broad categories of Design Reference Missions (DRM) to provide flexibility in risk characterization and assessment that will be applicable to human space exploration missions yet to be defined: Low Earth Orbit, Deep Space Sortie, Lunar Visit/Habitation, Deep Space Journey/Habitation, and Planetary. A Risk has a clear likelihood and consequence supported by evidence. Risks in the IRP are assigned Likelihood and Consequence (LxC) ratings and Risk Dispositions either from the HSRB or the HRP. The LxC ratings are assessed for two consequence categories (in-mission health and performance outcomes (Operations), and long-term health) based on scales defined by the HSRB and have associated colors (red, yellow, green) based on where the scores fall in the risk matrix. A Concern currently does not have sufficient evidence to perform an LxC assessment or determine a risk disposition for a given DRM; the objective of the research is to seek out the evidence necessary to generate an LxC assessment.

Source: Human System Risk Management Plan – JSC 66705


These LxC ratings are tracked in the PRR as an indication of progress of research work towards risk mitigation. They serve as one of several inputs to determine the research priority of each risk, helping HRP Management make decisions and allocate resources. The HSRB also designates Risk Dispositions with the LxC scores to indicate the HSRB's assessment of the adequacy of mitigation efforts (e.g., Requires Mitigation, Accepted). HRP does not assign Risk Dispositions for the sub-risks. The only Risk Dispositions related to the HRP sub-risks are those assigned are by the HSRB for the consolidated risk. The LxC ratings and Risk Dispositions are used as a tool to communicate to Agency management the seriousness of a risk to crew health and performance and the Office of the Chief Health and Medical Officer (OCHMO) position on future actions for the risk.

The HSRB maintains a risk record system for approved risk summary reports and supporting evidence for all the risks (including those not assigned to HRP) in its portfolio. This set of information is used by the HSRB to track and monitor the status of the risks, and to inform its decisions. The HRP utilizes the HSRB as a forum to communicate updates to risks resulting from HRP research and technology development activities.


For each risk, the responsible HRP Element identifies gaps in knowledge about characterizing the risk and ability to mitigate the risk. Gaps represent the critical questions that need to be answered to mitigate a risk and therefore serve to focus the areas of research work to address risk reduction milestones. In some cases a gap may map to more than one risk.


A task may partially or completely close a gap by better characterizing a risk or developing mitigation capabilities to reduce the risk to an acceptable level. In some cases, a task can address multiple gaps across multiple risks. Tasks are solicited through NASA Research Announcements (NRA), the Small Business Innovation Research (SBIR) program, NASA Request for Proposals, etc. In certain unique cases, the HRP may conduct research tasks in-house if there is insufficient time for the research solicitation or it is highly constrained research (e.g., involves aspects of on-going mission operations).



Each task, or progression of tasks, is designed to ultimately culminate in deliverables or products. Two organizations are the primary customers for the HRP deliverables: OCHMO and Human Exploration and Operations Mission Directorate (HEOMD).


Common deliverables include recommended standards (e.g., Permissible Exposure Limits), requirements (e.g., flight rules), risk characterization, countermeasures, clinical practice guidelines, and technology. Specifications for some deliverables are agreed upon with customers of the HRP products through the use of Customer-Supplier Agreements (CSAs). After deliverables are provided, the R&TD results are assessed for applicable updates to the evidence base as it impacts risks, gaps and tasks in order to achieve risk reduction goals as laid out in the PRR.

Two repositories contain human spaceflight data evidence:

  • Life Science Data Archive (LSDA) - contains research data from NASA-funded experiments.
  • Lifetime Surveillance of Astronaut Health (LSAH) - contains electronic health records (medical data) of all astronauts, including mission data. For the LSAH, astronaut medical data are collected per requirements in the Medical Requirements Integration Documents (MRID).

Both datasets are available from the Life Sciences Data Repositories and contain searchable, public data. In addition, a User’s Guide includes a description of data types (e.g., pooled, de-identified and identifiable data), data locations (by MRID category), the process for obtaining data (via the data request form), and a summary of applicable laws and regulations. The LSDA and LSAH repositories are continually updated with data resulting from HRP research as well as spaceflight missions and are available for use, as applicable.