Task Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms (Completed)
Last Published:  07/30/14 12:40:58 PM (Central)
Short Title: 0g SR Bone
Responsible HRP Element: Space Radiation
Supporting Org(s):
NSBRI
Funding Status: Completed - Task has been completed
Procurement Mechanism(s):
NASA Research Announcement
Aims:
  1. To test the hypothesis that simulated weightlessness of mice modulates the response of bone and bone marrow to radiation, both acutely and during tissue regeneration.
  2. To identify the target marrow-derived stem, progenitor and differentiated cell populations sensitive to the combined stimuli of simulated weightlessness and radiation.
  3. To explore the relevance of specific ROS/RNS and p53-dependent mechanisms for mediating cellular responses to combined simulated weightlessness and radiation.

 

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