Task Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms (Completed)
Last Published:  02/14/14 10:39:26 AM
Short Title: 0g SR Bone
Responsible HRP Element: Space Radiation
Supporting Org(s):
Funding Status: Completed - Task has been completed
Procurement Mechanism(s):
NASA Research Announcement
  1. To test the hypothesis that simulated weightlessness of mice modulates the response of bone and bone marrow to radiation, both acutely and during tissue regeneration.
  2. To identify the target marrow-derived stem, progenitor and differentiated cell populations sensitive to the combined stimuli of simulated weightlessness and radiation.
  3. To explore the relevance of specific ROS/RNS and p53-dependent mechanisms for mediating cellular responses to combined simulated weightlessness and radiation.


Integration/Unique Aspects: