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B1
B15
Osteo 4 (B1c, B11, N7)
Osteo
Bone Turnover Model: Initial Implementation
Task Book:
Entry Unavailable
Principal Investigator:
Pennline
Short Title:
Bone Model
Responsible HRP Element:
Human Health Countermeasures
Supporting Org(s):
Funding Status:
Active - Task currently funded
Procurement Mechanism(s):
Direct Contract
Aims:
Integration/Unique Aspects:
Resources
(
None Listed
)
Deliverables (
0
)
Mappings
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Bone Turnover Model: Initial Implementation
Related Tasks (59)
Nutritional Status Assessment: SMO-016E
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism During Space Flight and Recovery (Pro-K)
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Assess Vertebral Compression Fractures (MRID)
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Feasibility Study: QCT Modality for Risk Surveillance of Bone - Effects of In-flight Countermeasures on Sub-regions of the Hip Bone
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Rapid measurements of bone loss using tracer-less calcium isotope analysis of blood and urine
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss: SMO-021
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Integrated Resistance and Aerobic Training Study
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
A Quantitative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bed Rest Analog
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Monitoring Bone Health by Daily Load Stimulus Measurement during Lunar Missions
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Monitoring of Bone Loss Biomarkers in Human Sweat: A Non-Invasive, Time Efficient Means of Monitoring Bone Resorption Markers under Micro and Partial Gravity Loading Conditions
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Space Radiation and Bone Loss: Lunar Outpost Mission Critical Scenarios and Countermeasures
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Maintaining Musculoskeletal Health in the Lunar Environment
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Biomechanical Analysis of Treadmill Locomotion on the International Space Station
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Flywheel Prescription Optimization
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Ground-based Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Development of New Exercise Hardware for Exploration Missions
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
A New Harness For Use with Exercise Countermeasures-Validation of Improved Comfort and Loading with the Center for Space Medicine (CSM) Harness
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Exercise Plus Nutritional Supplement Studies
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
SPRINT Optimization Studies
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Reusable Handheld Electrolytes and Lab Technology for Humans
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Pilot Studies of Radiation Damage in Organ Tissues of Mice
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects
Common Item(s)
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Pharmaceutical Countermeasure Effects on Tissue-level Quality of Immobilized Bone
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Evaluate n-3 Fatty Acids as a Countermeasure for Bone Loss
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Simulated space radiation and weightlessness: vascular-bone coupling mechanisms to preserve skeletal health
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spacefllight
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
ESPRIT: Exercise Sensing and Pose Recovery Inference Tool
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
Wideband Single Crystal Transducer for Bone Characterization
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (NSBRI Postdoctoral Fellowship)
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship)
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Developing a new bone medical standard for long-duration astronauts based on bone strength estimated by Finite Element [FE] Modeling
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Increasing the Efficiency of Exercise Countermeasures for Bone Loss
Common Item(s)
B15: What exercise protocols are necessary to maintain skeletal health and can exercise hardware be designed to provide these? (merged into Osteo 7)
A Low Intensity Mechanical Countermeasure to Prohibit Osteoporosis in Astronauts During Long-Term Spaceflight
Common Item(s)
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
A Scanning Confocal Acoustic Diagnostic System for Non-Invasively Assessing Bone Quality
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Retention of Skeletal, Musculature, and Postural Status with a Non-invasive, Extremely Low-level Mechanical Signal: A Ground-based Evaluation of Efficacy
Common Item(s)
B1: a) Is there an increased lifetime risk of fragility fractures/osteoporosis in astronauts (Merged with Osteo 2); b) is bone strength completely recovered post-flight (merged with Osteo 3), and does BMD reflect it (Closed); c) what are the risk factors for poor recovery of BMD/bone strength? (Merged with Osteo 4)
Biochemistry Profile Surveillance
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Issues Related to Systemic Inflammatory Response
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Integrated Regulation of Bone and Muscle Metabolism by Simulated Microgravity
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Astronaut Bone Medical Standards Derived from Finite Element [FE] Modeling of QCT Scans from Populations Studies
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Bone Epidemiologic Analysis II
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
Validation of Bone Microarchitecture Technology – Animal Study
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Validation of Bone Microarchitecture Technology – Ground Study
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Validation of Bone Microarchitecture Technology – Flight Study
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Emerging Drug (TBD) Analogue Validation
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Emerging Drug (TBD) Flight Validation
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Flight Validation of an Integrated Nutritional, Pharmaceutical and Exercise CM
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Flexible Ultrasound – Correlation to Bone Measures
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Emerging Drug (DMab) Analogue Validation
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Emerging Drug (DMab) Flight Validation
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
Bone Measures Add-On to OP Summit Follow-On Study
Common Item(s)
Risk Of Early Onset Osteoporosis Due To Spaceflight
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Osteo Schedule
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