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Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spacefllight

Task Book: Entry Unavailable
Principal Investigator: Ferguson

Short Title: Sclerostin Mice

Responsible HRP Element: Human Health Countermeasures

Supporting Org(s):

NSBRI

Funding Status: Active - Task currently funded

Procurement Mechanism(s):

NASA Research Announcement

Aims:

Integration/Unique Aspects:

Resources (None Listed)

Deliverables (1)

Category:
Subcategory:

Description:

Customer:
Is there a signed Customer-Supplier Agreement? No

Delivery Milestone: 9/27/2012

Mappings

Risk Of Early Onset Osteoporosis Due To Spaceflight

Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spacefllight

Related Tasks (51)

Nutritional Status Assessment: SMO-016E

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism During Space Flight and Recovery (Pro-K)

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Assess Vertebral Compression Fractures (MRID)

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Feasibility Study: QCT Modality for Risk Surveillance of Bone - Effects of In-flight Countermeasures on Sub-regions of the Hip Bone

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Rapid measurements of bone loss using tracer-less calcium isotope analysis of blood and urine

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss: SMO-021

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	B3: What pharmaceuticals against bone loss are best used and how? (merged into Osteo 7)
	MO5: Determine how can osteoporosis treatments be employed? (merged into Osteo 7)
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Integrated Resistance and Aerobic Training Study

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Monitoring of Bone Loss Biomarkers in Human Sweat: A Non-Invasive, Time Efficient Means of Monitoring Bone Resorption Markers under Micro and Partial Gravity Loading Conditions

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Space Radiation and Bone Loss: Lunar Outpost Mission Critical Scenarios and Countermeasures

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	B3: What pharmaceuticals against bone loss are best used and how? (merged into Osteo 7)
	MO5: Determine how can osteoporosis treatments be employed? (merged into Osteo 7)
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Maintaining Musculoskeletal Health in the Lunar Environment

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Flywheel Prescription Optimization

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Ground-based Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Development of New Exercise Hardware for Exploration Missions

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

SPRINT Optimization Studies

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Reusable Handheld Electrolytes and Lab Technology for Humans

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Pilot Studies of Radiation Damage in Organ Tissues of Mice

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects

Common Item(s)
	B3: What pharmaceuticals against bone loss are best used and how? (merged into Osteo 7)

Pharmaceutical Countermeasure Effects on Tissue-level Quality of Immobilized Bone

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	B3: What pharmaceuticals against bone loss are best used and how? (merged into Osteo 7)

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Evaluate n-3 Fatty Acids as a Countermeasure for Bone Loss

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Simulated space radiation and weightlessness: vascular-bone coupling mechanisms to preserve skeletal health

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	B3: What pharmaceuticals against bone loss are best used and how? (merged into Osteo 7)
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Bone Turnover Model: Initial Implementation

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Wideband Single Crystal Transducer for Bone Characterization

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Developing a new bone medical standard for long-duration astronauts based on bone strength estimated by Finite Element [FE] Modeling

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

A Scanning Confocal Acoustic Diagnostic System for Non-Invasively Assessing Bone Quality

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Examination of Anti-Resorptive and Anabolic Treatments/Stimuli on Unloading Induced Osteoporosis

Common Item(s)
	B3: What pharmaceuticals against bone loss are best used and how? (merged into Osteo 7)

Bone Recovery Potential After Bisphosphonate and PTH Treatment of Disuse Osteoporosis

Common Item(s)
	B3: What pharmaceuticals against bone loss are best used and how? (merged into Osteo 7)

Biochemistry Profile Surveillance

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Issues Related to Systemic Inflammatory Response

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Integrated Regulation of Bone and Muscle Metabolism by Simulated Microgravity

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Astronaut Bone Medical Standards Derived from Finite Element [FE] Modeling of QCT Scans from Populations Studies

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Bone Epidemiologic Analysis II

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4 (B1c, B11, N7): We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Validation of Bone Microarchitecture Technology – Animal Study

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Validation of Bone Microarchitecture Technology – Ground Study

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Validation of Bone Microarchitecture Technology – Flight Study

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Emerging Drug (TBD) Analogue Validation

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Emerging Drug (TBD) Flight Validation

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Flight Validation of an Integrated Nutritional, Pharmaceutical and Exercise CM

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Flexible Ultrasound – Correlation to Bone Measures

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Emerging Drug (DMab) Analogue Validation

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Emerging Drug (DMab) Flight Validation

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Bone Measures Add-On to OP Summit Follow-On Study

Common Item(s)
	Risk Of Early Onset Osteoporosis Due To Spaceflight

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Schedules (1)

This task can be found in the following Risk schedules.

Osteo Schedule

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