Murine Tissue II
Responsible HRP Element:
Active - Task currently funded
|NASA Research Announcement
- To use a comparative biology approach and a transgenic mouse model that involves both in vitro and in situ approaches with two cancer development processes, genomic instability and aneuploidy, links them to each other and to specific mechanisms of mutagenesis at an endogenous autosomal locus in epithelial cells.
- To define links between the processes that lead to early establishment of genomic instability, aneuploidy, and mechanisms of autosomal mutagenesis found in many kinds of human epithelial cancers.