Short Title:
Oxidative CM
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Task currently funded
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Procurement Mechanism(s):
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| NASA Research Announcement |
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Aims:
Specific Aim 1: Characterize oxidative lung damage from repeated Radiation/hyperoxia
exposure in a novel mouse model of space-flight related challenge.
Mouse cohorts will be subjected to repeated rounds of sublethal (0.25Gy) total body
radiation, 8 hours of hyperoxia (100% O2) or a combination of both, 3 times weekly for
4 weeks and evaluated at 1 month (acute) and 2,3 and 4 months (Chronic) later for
oxidative damage, fibrosis and inflammation of lung tissues. Brain and blood tissues will
also be evaluated to determine systemic toxicity.
Specific Aim 2: Evaluate usefulness of dietary FS and FLC as countermeasure to oxidative
lung injury in a mouse model of radiation/hyperoxia relevant to space flight challenges.
Mouse cohorts will be placed on a flaxseed (FS) or flaxseed lignan component (FLC)
diets and subjected to the conditions described in Aim1. Lung tissues as well as Brain,
and blood will be collected after 1 month (acute) and compared to that collected after 2,3,
4 months (Chronic) with respect to oxidative damage, inflammation, fibrosis.
Integration/Unique Aspects:
Category:
Risk Characterization/Quantification
Subcategory:
Evidence
Description:
We hope that a major finding from the proposed project will be to establish FS and specifically SDG, as useful countermeasure agents from radiation damage associated with space exploration and serve so that future strategies can be can be designed to better protect crewmembers.
Customer:
HHC
Is there a signed Customer-Supplier Agreement?
No
Delivery Milestone:
9/30/2013