Short Title:
Integrated Fluid volume-Dulchavsky
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Task currently funded
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Procurement Mechanism(s):
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| NASA Research Announcement |
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Aims:
This is a flight definition study in a mixed astronaut and cosmonaut group, with multimodality complex evaluation protocols in pre-flight, in-flight, and post-flight phases.
The tilt table analog for microgravity-induced fluid shift is well known. The validity of the
model for microgravity-induced intracranial hypertension studies has recently been shown in experiments performed by the investigation team. In the preflight phase, this experiment will use an incremental tilt model to induce graded fluid shifts and acquire cardiac, vascular, intracranial, and ocular data, with concurrent monitoring of ICP surrogate measures. Spaceflight phase will follow to compare individual responses to microgravity with the preflight responses. Post-flight phase will not require early postflight BDC, and will include minimal postural manipulations, rather considering a limited number of parameters in upright and supine positions associated with ocular system and possible persisting ICP elevation.
Specific Aims:
1. Characterizing fluid distribution in the steady state of continuous microgravity
2. Determining the physiological and potential health effects of microgravity-associated fluid redistribution on the cardiovascular and central nervous (CNS) systems.
3. Determining best combinations of non-invasive technologies related to fluid shifts and
ICP elevation that are most predictive in estimating the absolute ICP and trends thereof during space flight?
4. Assessing the acute fluid volumetric effects of the Braslet and Lower Body Negative Pressure (LBNP) countermeasures on central, peripheral vascular systems and CNS/ocular systems.
5. Identifying markers of susceptibility to the development of ICH in microgravity.
Integration/Unique Aspects:
This study is planned to be integrated with two other flight proposals from the 2011 NRA: M. Stenger and A. Hargens.
Flight Resources
| Number of Subjects
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12
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| When are operations required?
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Pre/In/Post
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| When is an approved proposal expected?
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11/1/2012
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Frequency and type of in-flight sessions:
early, mid, late
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Type of in-flight sessions:
ultrasound, ICP testing, intervention characterization
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Type of in-flight sample collection:
data collection
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Hardware/Software Requirements:
TBD
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BDC Requirements:
ultrasound, ICP testing
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Category:
Countermeasures
Subcategory:
Prototype Hardware, Pharmaceutical, Nutritional Supplement
Description:
A final report detailing the changes in fluid shift during space flight and potential countermeasure testing.
Customer:
HHC
Is there a signed Customer-Supplier Agreement?
No
Delivery Milestone:
9/29/2017