Short Title:
Virulence (Cellular)
Responsible HRP Element:
Space Human Factors and Habitability
Funding Status:
Planned - Task expected to be within budget
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Procurement Mechanism(s):
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| NASA Research Announcement |
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Aims:
- Elucidation of the cellular mechanisms of the host and pathogens by which changes in microbial virulence are affected, and the potential effects that changed virulences may have upon a host during flight (ground studies and flight studies).
- An assessment, using microorganisms or microorganisms with host surrogate models, to determine changes in microbial responses to spaceflight/spaceflight analogue environments that would indicate alterations in the risk of infectious disease during spaceflight missions.
Integration/Unique Aspects:
This task would also support gaps AEH 8; AEH 9; AEH 10.
Flight Resources
| Number of Subjects
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0
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| When are operations required?
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Pre/In/Post
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| When is an approved proposal expected?
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3/31/2014
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Frequency and type of in-flight sessions:
N/A
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Type of in-flight sessions:
Operational activities, such as turning equipment on/off; possible sample transfer
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Type of in-flight sample collection:
Sample collection possible from cultures depending on design
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Hardware/Software Requirements:
hardware for culturing microbes
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BDC Requirements:
Sample collection.
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Category:
Risk Characterization/Quantification
Subcategory:
Evidence
Description:
Data from these studies will support an assessment of the risk to crew health that may be posed by increased virulence of pathogenic organisms that may result from their exposure to conditions of space flight. NRA solicited research (Host Microbe Interactions) is expected to begin in FY15 and reports describing findings are expected to be provided by the end of FY18.
Customer:
SHFH
Is there a signed Customer-Supplier Agreement?
No
Delivery Milestone:
9/28/2018