Task Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration
Last Published:  07/30/14 12:40:58 PM (Central)
Short Title: Testosterone
Responsible HRP Element: Human Health Countermeasures
Supporting Org(s):
Funding Status: Active - Task currently funded
Procurement Mechanism(s):
NASA Research Announcement
Aims:

Long duration space flight is associated with loss of muscle mass and strength and loss of bone mass. To date exercise countermeasures have not been fully effective. Current evidence suggests that the combination of testosterone, amino acids, and exercise will optimize the effectiveness of the existing exercise and nutritional countermeasures. This intervention may improve exercise effectiveness or allow for a reduced volume of required exercise.

The specific aims of this study are to:

  1. Determine the effect of monthly cycled testosterone replacement in conjunction with resistance exercise on muscle mass, muscle strength, bone mass and markers of bone metabolism in men aged 35-55.
  2. Determine the effect of daily leucine supplementation in conjunction with resistance exercise on muscle mass, muscle strength, bone mass and markers of bone metabolism in women aged 35-55.
Integration/Unique Aspects:
This study is one of several potential pharmaceutical or nutritional countermeasures that if promising could be selected for flight validation (see Flight validation studies of pharmaceutical or nutritional supplements).
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