Last Published:  03/26/21 03:33:57 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open

Initial State of Gap: There are numerous possible sources of oxidative stressors during space flight, including radiation, oxygen exposure, diet, or changes in metabolism.  For one recent piece of evidence, data from the Nutrition SMO recently identified iron status as a factor that is closely related to biomarkers of oxidative damage during space flight.

Interim steps: 

      1. Evaluate ongoing flight experiments for macro or micro nutrients correlated with biomarkers of oxidative damage, and determine if mission architecture  affect these relationships. [10% gap closure]
      2. Determine effects of increased iron stores on physiological systems, including bone, muscle, cardiovascular, and oxidative damage. [40% gap closure]
      3. Determine whether specific nutrients can mitigate oxidative damage due to radiation exposure. Evaluate countermeasures to lower iron status and determine effect on physiological systems, including bone, muscle, and cardiovascular. [40% gap closure]
      4. Evaluate nutritional countermeasures as radioprotectants. [10% gap closure]

Approach: This gap will be addressed with a combination of animal, ground analog and flight experiments. Animal/cellular studies will be used to evaluate the effects of radiation on oxidative damage. Ground based analogs for flight will be used to study aspects of nutrition changes know to be correlated with oxidative damage.  Flight studies assess interrelationship of dietary intake with biochemical measures of oxidative stress.

Target for Closure
Identify nutrients that are correlated with oxidative damage during spaceflight and evaluate their suitability for use as a countermeasure.
Risk Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
You are here! Gap N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

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