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Renal
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Integrative CM
B8: Do pharmaceuticals work effectively in spaceflight to prevent renal stones?
Last Published:
03/26/21 03:33:57 PM (Central)
Responsible Element:
Exploration Medical Capability (ExMC)
Status:
Closed
Closure Rationale
Sufficient knowledge exists with respect to the impact of pharmaceuticals of the renal stone formation process in spaceflight. This information will be integrated into
ExMC’s
future exploration medical system models and trade space analysis tools.
Closure Documentation:
No Closure Documentation Available
Description
No description available.
Target for Closure
No Target for Closure available.
Mappings
Risk of Renal Stone Formation
B8: Do pharmaceuticals work effectively in spaceflight to prevent renal stones?
Completed
The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)
Task Book:
Entry
Principal Investigator:
Levine, Benjamin
Short Title:
Integrative CM
Responsible HRP Element:
Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Test an integrated countermeasure that will be effective against cardiovascular deconditioning, skeletal muscle atrophy, and bone demineralization, and that ultimately can be applied practically abroad the International Space Station or a mission to Mars.
Resources
(
None Listed
)
Deliverables (1)
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Provide information that will assist in the development of an integrated countermeasure for cardiovascular deconditioning.
PI Publications (excerpt)
Fu Q, VanGundy TB, Galbreath MM, Shibata S, Jain M, Hastings JL, Bhella PS, Levine BD. "Cardiac origins of the postural orthostatic tachycardia syndrome." J Am Coll Cardiol. 2010 Jun 22;55(25):2858-68.
Otto C, Hamilton DR, Levine BD, Hare C, Sargsyan AE, Altshuler P, Dulchavsky SA. "Into thin air: extreme ultrasound on Mt Everest." Wilderness Environ Med. 2009 Fall;20(3):283-9.
Shibata S, Perhonen M, Levine BD. "Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest." J Appl Physiol. 2010 May;108(5):1177-86.
Wood HE, Levine BD, Babb TG. "Ventilatory responses to exercise and hypercapnia following 18 days of head-down rest." Aviat Space Environ Med. 2009 Apr;80(4):395-9.
Internal Customers:
Human Health Countermeasures
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Documentation:
No Documentation Available
Related Gaps (9)
B5: What is the current state of knowledge regarding renal stone formation due to spaceflight?
Common Item(s)
Risk of Renal Stone Formation
B6: What are the contributing factors other than loss of bone mineral density?
Common Item(s)
Risk of Renal Stone Formation
B7: Is it necessary to increase crew fluid intake and, if possible, to what extent will it mitigate stone formation?
Common Item(s)
Risk of Renal Stone Formation
B9: What is the frequency of post-flight stone formation; the incidence and types of stones; and the time course of stone formation? How does stone formation correlate with food intake and hydration status?
Common Item(s)
Risk of Renal Stone Formation
B16: Can inhibitors of stone formation be sufficiently provided through dietary sources?
Common Item(s)
Risk of Renal Stone Formation
N13: Can renal stone risk be decreased using nutritional countermeasures?
Common Item(s)
Risk of Renal Stone Formation
Med12: We do not have the capability to mitigate select medical conditions.
Common Item(s)
Risk of Renal Stone Formation
Renal-101: We do not have the capability to mitigate renal stones in spaceflight.
Common Item(s)
Risk of Renal Stone Formation
CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.
Common Item(s)
The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)
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Risk Approach Plans (1)
This gap can be found in the following Risk Approach Plans.
Renal Risk Approach plan
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