Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
Use a hypothesis driven targeted metabolomics approach to identify
mitochondrial related metabolites in urine and serum that are associated with bed rest-induced
physiological manifestations and protected against by countermeasures (testosterone and
exercise).
Use an untargeted metabolomics approach to identify novel metabolites and
pathways in serum associated with physiological changes induced by bed rest and protected
against by countermeasures.
Test whether serum metabolites identified in Aims 1 & 2 have the potential to
regulate mitochondrial driven cellular metabolism and if specific changes in metabolism may be
a means of detecting the risk for or monitoring the progression of physiological outcomes
induced by bed rest.