HRR - Gap - M6: Develop pre-flight, in-flight, and post-flight evaluations to determine if muscle function standards are met.

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M6: Develop pre-flight, in-flight, and post-flight evaluations to determine if muscle function standards are met.

Content in this Gap was merged from 1 other Gap

Last Published: 11/23/20 11:55:10 AM (Central)

Responsible Element: Human Health Countermeasures (HHC)

Status: Open

Description

Initial State: Currently there are no tests or evaluations that are used with the specific intention to access muscle performance readiness during missions. The goal of filling this gap is the development of a reliable test(s) that can be performed both before a mission and during critical times during a mission (e.g. before a high workload EVA or prior to landing). The test would be aimed directly at determining if established muscle fitness standards (see gap M4) we being met. Just as muscle fitness standards are expected to be design reference mission (DRM)-specific, in-flight evaluations protocols and hardware may be DRM specific as well due to limitations in available equipment during any particular exploration mission.

Interim Stages:
Validation of test protocol(s) against functional task performance
Identification of new and/or existing ground and in-flight exercise hardware that is compatible with tests

Approach: Human-in-the-loop testing.

Target for Closure

Identification of simple hardware and protocols that produce validated muscle fitness data.

Mappings

Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M6: Develop pre-flight, in-flight, and post-flight evaluations to determine if muscle function standards are met.

Active

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Task Book: Entry
Principal Investigator: Rana, Brinda

Short Title: metabolomic alterations

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Identify metabolomic profiles associated with simulated space flight induced

physiological outcomes.

Identify changes in metabolomic pathways associated with simulated space flight

induced physiological changes by applying metabolomic approaches described in Aim 1 on

longitudinally collected urine and serum samples.

Test whether plasma metabolites have the potential to regulate cellular

metabolism and if specific changes in metabolism may be a means of detecting the risk for or

monitoring the progression of physiological outcomes induced by a simulated space flight

Resources (Ground Analog)

Deliverables (1)

Completed

Reliability of the Power Cycle: A Comparsion to Current NASA Exercise Laboratory Muscle Performance Tests

Task Book: Entry Unavailable
Principal Investigator: Ploutz-Snyder, Lori

Short Title: Power Cycle

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:
To evaluate the reliability of a novel piece of exercise testing hardware for measuring muscle performance.

Resources (None Listed)

Deliverables (1)

Identification of Muscle Fitness Standards For Exploration Mission Tasks

Task Book: Entry Unavailable
Principal Investigator: Ryder, Jeffrey

Short Title: Mission Tasks - Muscle

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:
The proposed research is more operational than hypothesis driven. Previously validated techniques will be used to identify fitness thresholds for performance of a new set of mission-related tasks. The Specific Aim is to identify thresholds of muscle performance, below which task performance is impaired. A variety of muscle performance measurements will be evaluated; this allows flexibility in the eventual development of a readiness test since it is not yet known what muscle performance monitoring capability will be in future vehicles.

Resources (Other)

Deliverables (1)

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Task Book: Entry
Principal Investigator: Ade, Carl

Short Title: omics markers of cardio and bone

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Determine if tissue-specific cardiovascular-health related circulating

endothelial microparticles and microRNA (c-miRNA) are altered following 30 days HDBR and

how they relate to changes in maximal aerobic capacity, orthostatic tolerance, and

intraocular pressure.

Determine if bone-health specific circulating biomarkers and c-miRNA are

altered following 30 days HDBR and if they are related to changes in bone turnover and bone

mass changes.

Resources (Ground Analog)

Deliverables (1)

Category:
Subcategory:

Description:

1) Determine the effects of simulated spaceflight on endothelial phenotype via changes in

circulating endothelial microparticles

2) Determine the effects of simulate spaceflight on circulating microRNA levels

3) Determine the role of cardiac-specific microRNA on changes in ventricular volume and

performance.

4) Evaluate the relationship between cardiovascular tissue-specific microRNAs on the

decrease in aerobic exercise capacity following simulated spaceflight

5) Determine the effects of simulated spaceflight on serum concentrations of Sclerostin

6) Determine the role changes in Sclerostin has on standard measurements of bone

mineral density

7) Determine the role of bone-specific microRNA on standard measurements of bone

mineral density

8) Provide a group of potential biomarkers that can be used as an in-flight capability to

monitor cardiovascular and bone physiology.

Internal Customers:
Human Health Countermeasures
External Customers:
None Is a Customer-Supplier Agreement (CSA) Required? No

Documentation:

No Documentation Available

Related Gaps (12)

M14: Indentify adjuncts to exercise countermeasures that can be used to better mitigate muscle loss.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M1: What is the current state of knowledge regarding exercise performance?

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M4: Establish muscle function standards for successful completion of mission tasks.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	Identification of Muscle Fitness Standards For Exploration Mission Tasks

M7: Develop the most efficient and effective exercise program for the maintenance of muscle function.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M9: Identify and validate exploration countermeasure hardware for the maintenance of muscle function.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M2: Characterize in-flight and post-flight muscle performance.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	Reliability of the Power Cycle: A Comparsion to Current NASA Exercise Laboratory Muscle Performance Tests

M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M24: Characterize the time course of changes in muscle protein turnover, muscle mass, and function during long duration space flight.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Common Item(s)
	Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)
	Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

SANS-202: Determine if genetic/metabolic/anatomic dispositions and biomarkers, and sex differences have a contributing role in the development of ocular manifestations.

Common Item(s)
	Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

EVA-101: Determine limitations of EVA performance and physiological metrics shortly post-landing on a planetary surface (with compromised physiology based on flight duration).

Common Item(s)
	Identification of Muscle Fitness Standards For Exploration Mission Tasks

CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)
	Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

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PRRs (1)

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Ground-Based Flight Analogs	Bedrest [e.g., envihab, other bedrest facilities]
Number of Subjects	24

Ground-Based Flight Analogs	Bedrest [e.g., envihab, other bedrest facilities]
Number of Subjects	24