Gap Acute - 2: What quantitative procedures or theoretical models are needed to extrapolate molecular, cellular, or animal results to predict acute radiation risks in astronauts? How can human epidemiology data best support these procedures or models?
Last Published:  07/31/18 09:30:04 AM (Central)
Responsible Element: Space Radiation (SR)
Status: Open
Description


Initial State of Gap:

The SRPE Risk Assessment Project has developed sophisticated nonlinear kinetics models of bone marrow stem cells and various blood system components to describe and provide accurate descriptions of human and other species responses to acute and chronic irradiation. These organ dose projection models are incorporated in a software package called ARRBOD and can be used by mission planners, radiation shield designers, space operations, and space biophysics researchers to assess clinically significant deterministic health effects including in-flight performance degradation from exposure to large SPEs. The ARRBOD model uses historical data from terrestrial exposures and requires model updates with radiobiological data specific to the space environment.  

 

 

Approach:

 

Ground-based, peer-reviewed research using appropriate animal models is needed to acquire data (see Acute Gap 1) to support refinement of acute radiation risk projection models with data specific to the space flight environment. Acute radiation response model updates will be made as radiobiological data is generated with proton exposures at historical SPE-relevant energies and dose rates including data on impact of inhomogeneous dose distributions that may occur with SPE exposures.  

 



 

 


Target for Closure
  • Acute Radiation Response Models updates with radiobiological data using space relevant proton energies, dose-rates, and total exposures possible during EVA’s.
  • Acute Radiation Response Models model updates quantifying the interaction of skin, immune system and microgravity effects on the BFO and prodromal risks.
Mappings
Risk Risk of Acute Radiation Syndromes Due to Solar Particle Events (SPEs)
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