Gap Fracture 2: We need to characterize the loads applied to bone for standard in-mission activities.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Exploration Medical Capability (ExMC)
Status: Closed
Closure Rationale
Sufficient knowledge exists with respect to the types of loads applied to bone during standard nominal spaceflight operations. Computational models that predict the likelihood of bone fracture during spaceflight have been developed and validated ( ExMC has no plans for new research or work on this gap. 
Closure Documentation:
No Closure Documentation Available
Initial State:

The Bone Fracture Risk Module [BFxRM] of the Integrated Medical Model [IMM] was developed to estimate the probability of fracture for reference missions to moon and Mars.  In this predictive module, the applied mechanical loads to bones were calculated with biomechanical models/algorithms (Nelson et al. Annuals of Biomedical Engineering, 2009). In addition, the modeling of fracture risk focused on activities that would result in fractures of high severity for an exploration mission, i.e., spinal, femoral and wrist fractures. Hence, the mechanical loads to these specific skeletal sites were estimated for the following activities:  lifting heavy objects up to 60 kg, accidental falls or intentional jumps from 1-2 meters – following an extensive review of the literature on terrestrial fracture incidence (Nelson, 2009) and design reference missions to the moon and Mars.

Interim Stages (Sequential):
  1. Survey potential in-mission activities (nominal and off-nominal) that would mechanically load astronaut bones. (30%)
  2. Determine relevant bones mechanically loaded by in-mission activities. (5%)
  3. Calculate expected loads to relevant bone(s) for each expected activity (#1). (65%)

Develop a method for estimating/quantifying loads for in-flight tasks and activities.
Target for Closure
Determined probability of mechanically overloading bones for critical in-mission activities
Risk Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
You are here! Gap Fracture 2: We need to characterize the loads applied to bone for standard in-mission activities.

Multi-Disciplinary Research Plans

No Documentation Available