Last Published:  03/26/21 03:33:57 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open

Initial State of Gap: Differences in folate-, vitamin B6-, and vitamin B12-dependent one carbon metabolism have been associated with crewmembers that have had vision-related issues during and after ISS flights.  Whether this is predictive of problems is yet to be documented, and whether or not nutritional countermeasures can help mitigate changes is unknown and must be tested.       

Interim steps: 

    1. Identify the role of one-carbon pathway polymorphisms in VIIP related issues [50% gap completion]
    2. If an initial relationship is found, additional studies and/or gaps may be required to understand mechanisms and means of mitigating these effects in individual crewmembers [50% gap completion]

Approach: The general research approach will be to complete the  1-C Study, identify relationships of 1-C metabolism with CO2 and/or other factors, and identify whether altering 1-C metabolism through diet modulation can alter risks of VIIP factors.  Other research will involve analysis of the Integrated Nutrition Countermeasure study, which will provide a detailed evaluation of dietary intake in relation to vision and related issues during and after long-duration spaceflight. 

Target for Closure
Determine the role of nutrition in vision related issues during spaceflight. 
Risk Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
You are here! Gap N7.3: We need to identify the most important nutritional factors for ocular health.

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