Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: The immune system is a sentinel system that exchanges information and is influenced by almost every other body system. Inflammation influences bone formation and resorption (osteo-immunology), nutritional status distinctly influences immune status and functional capacity, and both psychological and physiological stress influence immunity. Although a set of primary markers for spaceflight immune status has been established (T cell function, VZV reactivation, etc.), there are likely to be myriad other translational and relevant biomarkers as yet unestablished.
Research approach: HRP is funding several studies which have a biomarker component and is monitoring several studies funded by International Partners. HRP may fund additional studies via solicited and directed mechanisms as deemed necessary. Efforts may include data mining to tabulate currently known dysfunctions with potential biomarkers, and identification of new biomarkers in upcoming studies. 
Target for Closure
Validated immune biomarkers that will allow monitoring of immune status during flight.
Mappings
Risk Risk of Adverse Health Event Due to Altered Immune Response
You are here! Gap IM-105: Identify immune biomarkers that correlate with known spaceflight-related immune dysfunction and immune outcomes, as a first step in designing in-flight monitoring paradigms.
Active
Completed
Planned-Funded

Multi-Disciplinary Research Plans

Documentation:
No Documentation Available