Gap IM-201: Based on immune dysfunction biomarkers identified in Scientific Objective 1, identify, develop, and implement in-flight immune function monitoring tools for support of research during Gateway, Lunar, and Mars missions.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: While development of clinical diagnostic tools for exploration missions is under the purview of HRP’s Exploration Medical Capabilities Element (ExMC), there is also an interest to have the capability to monitor subclinical immune changes that while not clinically actionable have an impact on growing our knowledge of immune function under deep-space conditions, as well as on monitoring countermeasure effectiveness. At present, there is little to no medical laboratory analysis capability on board ISS, and there have been many unsuccessful attempts to develop microgravity-compatible blood analysis capability. The recently validated biomolecule sequencer may afford the capability to monitor reactivation of latent herpes viruses during space flight. Several instruments in development by space agencies or commercial providers may soon be available to provide blood analysis. These include the SBIR-developed rHEALTH instrument, and the Canadian Space Agency’s BIO-A/Power-Blade efforts.

Research approach: Identify commercial-off-the-shelf (COTS) devices that can support immune function testing in-flight so that bio-samples do not need to be stored and returned to Earth for analysis post-mission. If no such devices are available in the commercial market, develop such technology as an exploration-forward effort. Because our focus is on subclinical immune changes that are not necessarily clinically-actionable, such devices will likely not overlap with the traditional clinical lab equipment that will be in use by MedOps during exploration missions. COTS devices might be available but may need to be miniaturized for flight.
Target for Closure
Clinically-validated immune function monitoring tools for in-mission use.
Mappings
Risk Risk of Adverse Health Event Due to Altered Immune Response
You are here! Gap IM-201: Based on immune dysfunction biomarkers identified in Scientific Objective 1, identify, develop, and implement in-flight immune function monitoring tools for support of research during Gateway, Lunar, and Mars missions.
Active

Multi-Disciplinary Research Plans

Documentation:
No Documentation Available