Gap IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: NASA does not have a validated countermeasure for spaceflight-associated immune system dysregulation. Vitamin D supplementation has been proven to mitigate latent virus reactivation in the Antarctica analog. An international, multi-disciplinary group of experts was convened in 2018-2019 to discuss different aspects of a future immune countermeasure, and a specific candidate protocol was formulated and published in a pair of articles in the journal Frontiers. Several components of the proposed multi-pronged countermeasure are nutritional in nature, including a diet enriched with anti-oxidants, flavonoids, lycopene, lutein, sterols, and omega-3 fatty acids, various nutritional supplements, and probiotics.
Research approach: Several HRP-funded efforts are underway or in planning phases. An ISS flight study is currently evaluating a diet enriched with anti-oxidants, flavonoids, lycopene, lutein, sterols, and omega-3 fatty acids, and its effects on physiological, psychological and immune measures. A similar ground-based study evaluating this same dietary intervention was completed in the HERA isolation analog. A study is being planned to take place in the Antarctic Palmer Station that will evaluate an integrated immune countermeasure with nutritional and probiotic components.
Target for Closure
Validated nutritional countermeasures for prevention and mitigation of immune dysfunction.
Mappings
Risk Risk of Adverse Health Event Due to Altered Immune Response
You are here! Gap IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures
Active
Completed
Planned-Funded

Multi-Disciplinary Research Plans

Documentation:
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