Gap IM-501: Test the finalized, integrated, multi-component immune countermeasure in flight.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: At present NASA does not have a validated countermeasure for spaceflight-associated immune system dysregulation. An international, multi-disciplinary group of experts was convened in 2018-2019 to discuss different aspects of a future immune countermeasure, and a specific candidate protocol was formulated and published in a pair of articles in the journal Frontiers. The proposed countermeasure is muti-pronged and includes nutritional, pharmacological, and psychophysiological components, all expected to work in tandem. While components of this integrated countermeasure will be tested separately, this gap captures the validation of the combined countermeasure, will all its components, in the spaceflight environment, while performing multi-system monitoring, to determine effectiveness of the countermeasure.
Research approach: Conduct a final validation/demonstration of the integrated, multi-component immune countermeasure in flight, combining the components previously tested separately.
Target for Closure
Validated comprehensive countermeasure for prevention/mitigation of immune dysfunction. 
Mappings
Risk Risk of Adverse Health Event Due to Altered Immune Response
You are here! Gap IM-501: Test the finalized, integrated, multi-component immune countermeasure in flight.
Active
Planned-Funded

Multi-Disciplinary Research Plans

Documentation:
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