Gap SANS-103: Determine whether ground-based induced fluid shifts lead to ocular manifestations.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: SANS outcomes have developed in humans exposed to the spaceflight analog of strict 6-degree head-down tilt bed rest. It is not known if the underlying mechanism causing SANS outcomes during spaceflight and bed rest are similar. In addition, it is not known if the presentation of SANS signs and symptoms is similar (preliminary analysis has outlined differences and further analyses are underway).

Research approach
: HRP has been and will continue to pursue studies using acute head-down posture changes/tilts and long-duration head-down bed rest as a platform to investigate and clarify the effects of head-ward fluid shifts on the eye and the brain. Such investigations involve assessments of ocular and brain structural and functional changes with a comparison to data collected from flown astronauts. An understanding of the role of tissue weight and hydrostatics and how they differ in flight compared to head-down posture will also be pursued.
Target for Closure
Confirmation or non-confirmation of the role of headward fluid-shifts induced by ground-based head down bed rest on development of SANS-like manifestations.
Mappings
Risk Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
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Multi-Disciplinary Research Plans

Documentation:
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