Gap SANS-104: Determine whether ocular manifestations can be induced by fluid shifts in rodents and whether this model can be used for more detailed mechanistic insights.
Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: Rodent models of SANS have the potential to provide insight into the cellular- and tissue-specific changes that cause SANS findings and will allow for more targeted countermeasure development. Despite differences between anatomical structures of the eyes in rodents and humans, it is unknown if the spaceflight-analog of rodent hind-limb unloading will lead to the development of SANS signs, similarly to the use of strict head-down tilt bed rest in humans.

Research approach: A long-duration hind-limb unloading (HLU) study in rats will provide data on IOP, ICP, retinal histology, and changes in biomarkers. In addition, mice will be flown on the ISS for a period of 30 days, and changes in arterial, venous, and lymphatic function and their relationship to SANS signs in the mice will be investigated. These studies will be used to determine if rodent work is a useful tool for investigating SANS mechanisms.
Target for Closure
Determination if rodents exposed to HLU or spaceflight demonstrate SANS signs. If yes, this model can be used to identify mechanisms underlying SANS signs and test targeted countermeasures.
Mappings
Risk Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
You are here! Gap SANS-104: Determine whether ocular manifestations can be induced by fluid shifts in rodents and whether this model can be used for more detailed mechanistic insights.
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