Last Published:  07/30/21 01:05:31 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Present state of knowledge: Vascular fluid that is filtered into the interstitial space is returned to the vascular system via the lymphatic system. Recently, a similar system has been identified in the brain that clears metabolic waste products and is known as the glymphatic system. This system functions during sleep and it is hypothesized that impaired or reduced sleep may reduce glymphatic function and contribute to a variety of long-term cognitive changes in humans on Earth. It is unknown if weightlessness, headward fluid shifts, or alterations in sleep duration and/or quality in astronauts during spaceflight affect the functioning of this system, or how this system is affected during bed rest.

Research approach
: Glymphatic research is still a nascent research field, and its assessment in humans is still limited. Both HFBP as the leading HRP Element for this work, as well as HHC as the Element charged with investigating the SANS risk, are following developments in terrestrial research capabilities and will consider animal and human studies as the capabilities to monitor the glymphatic system matures.
Target for Closure
An understanding of the potential role of glymphatic dysregulation due to weightlessness, headward fluid shifts, chronic mildly elevated ICP, and in-flight alterations in sleep duration and/or quality, as well as any relationship to SANS or other functional outcomes.
Risk Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
You are here! Gap SANS-204: Determine if sleep/glymphatics has a contributing role in the development of ocular manifestations.

Multi-Disciplinary Research Plans

No Documentation Available