Gap Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.
Last Published:  11/23/20 11:55:10 AM (Central)
Responsible Element: Space Radiation (SR)
Status: Open
Description

A threat to astronaut health associated with Mars missions is the distance from Earth. Unlike ISS or Lunar missions, the ability to return to Earth for robust medical treatment is impossible. The capability to assess an astronaut’s individual susceptibility prior to flight, monitor astronaut health in mission, predict and monitor astronaut health post-flight, and provide an avenue for early detection of high risk cancers and other degenerative effects across astronaut lifespan is important to minimize the long term health consequences of space radiation exposure and inform standard of care. Chromosome aberrations have previously been assessed in astronauts pre- and post-flight. Therefore, identification and validation of new and emerging biomedical approaches is necessary for the surveillance of astronaut health over their lifetimes (including pre-flight, in mission, and post-flight) and assessment of risks to long term health pre-flight, in mission, and post-flight remains a paramount endeavor.

Approach 
Data mining of both animal and human clinical data, tech watches, inter-agency collaboration for identification of potential biomarkers. Ground-based research using in vitro and in vivo models as well as systems biology approaches to leverage animal and clinically relevant human datasets to assess and validate novel biomarkers for personalized risk assessment, disease monitoring, and countermeasure development and testing.


Target for Closure
  • Identification and validation of candidate biomarkers to determine individual radiation susceptibility and longitudinally monitor astronaut health to better estimate, personalize, and reduce risk of long-term health consequences of space radiation exposure as well as inform standard of care.
  • Initial recommendations for clinical practice guidelines incorporating biomarkers into standard measures for future missions.
Mappings
Risk Risk of Radiation Carcinogenesis
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