Short Title: Hypoxia Last Published:  07/30/21 01:05:31 PM (Central)
Element: Human Health Countermeasures (HHC)
Evidence:  Report
Risk Master Logic Diagram:  Diagram
Point of Contact:  Andrew Abercromby
HRP Risk Status: Inactive [no current ongoing research]
Inactive Rationale
While Exploration Atmosphere research and operational development is of high importance, much of this work is now funded by organizations other than HRP, in a collaborative joint effort with HRP as a stakeholder. Details of the work that is already being done (or planned to be done) may be found in the comprehensive NASA technical paper “Integrated Extravehicular Activity Human Research and Testing Plan” (NASA/TP-2019-220232). The impact of using the exploration atmosphere (8.2 psi/34% O2) on various physiological systems has been previously evaluated and summarized in an evidence report. No physiological concerns have been identified, however, the effects of such as atmosphere on the development of SANS is unknown. As part of HRP’s new strategy, that question will be addressed in a future study that will combine head-down tilt bedrest with exposure to the exploration atmosphere. This planned study is captured in the SANS science strategy, and the former gap ExAtm1 has been merged into the new gap SANS-201.
Inactive Documentation:
No Inactive Documentation Available
Risk Ratings and Dispositions per Design Reference Mission (DRM) Category
DRM CategoriesMission Type and
Duration
OperationsLong-Term Health
LxCRisk Disposition *LxCRisk Disposition *
Low Earth OrbitShort
(<30 days)
3x1Accepted with Monitoring3x1Accepted
Long
(30 days-1 year)
3x1Accepted with Monitoring3x2Requires Mitigation
Lunar OrbitalShort
(<30 days)
3x1Accepted with Monitoring3x1Accepted
Long
(30 days-1 year)
3x1Accepted with Monitoring3x2Requires Mitigation
Lunar Orbital
+ Surface
Short
(<30 days)
3x1Accepted with Monitoring3x1Accepted
Long
(30 days-1 year)
3x1Accepted with Monitoring3x2Requires Mitigation
MarsPreparatory
(<1 year)
3x2Accepted with Monitoring3x2Requires Mitigation
Mars Planetary
(730-1224 days)
3x2Accepted with Monitoring3x2Requires Mitigation
Note: LxC is the likelihood and consequence rating. The information above was last approved by the Human System Risk Board in 7/2020.
Risk Statement

Given that future human exploration missions require a robust, flexible Extravehicular Activity (EVA) architecture not provided with existing approved operational prebreathe protocols, but that might be met by the use of a reduced pressure cabin atmosphere enabling staged denitrogenation, there is a possibility that this atmosphere could result in compromised health and performance to the crewmember due to exposure to mild hypobaric hypoxia.

Gaps (6)