Risk Risk of Adverse Health Event Due to Altered Immune Response
Short Title: Immune Last Published:  11/23/20 11:55:09 AM (Central)
Element: Human Health Countermeasures (HHC)
Evidence:  Report
Risk Master Logic Diagram:  Diagram
Point of Contact:  Brian Crucian
HRP Risk Status: Active [current research ongoing]
Risk Ratings and Dispositions per Design Reference Mission (DRM) Category
DRM CategoriesMission
OperationsLong-Term Health
LxCRisk Disposition *LxCRisk Disposition *
Low Earth Orbit6 months3x2Accepted with Monitoring3x1Accepted
1 year3x2Accepted with Monitoring3x1Accepted
Deep Space Sortie1 month3x2Accepted with Monitoring3x1Accepted
Lunar Visit/
1 year3x2Accepted with Monitoring3x1Accepted
Deep Space
1 year3x2Accepted with Monitoring3x1Accepted
Planetary3 years3x3Requires Mitigation3x2Requires Mitigation
Note: LxC is the likelihood and consequence rating. The information above was last approved by the Human System Risk Board in 1/2015.
Risk Statement
Given that exposure to orbital spaceflight results in persistent dysregulation of the immune system, which leads to reactivation of latent herpes-viruses and likely to an increased clinical incidence, including rashes and hypersensitivity reactions, there is a possibility that certain diseases will occur during exploration class missions.
Gaps (12)