HRR - Task - Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

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Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed) (Completed)

Last Published: 07/29/22 01:33:24 PM (Central)

Task Book: Entry
Principal Investigator: Levine, Benjamin

Short Title: Cardiac Risk - Imaging

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Identify all clinical events in the Aerobics Center Longitudinal Study (ACLS) database. The researchers will identify and verify all myocardial infarctions, new onset angina and revascularization procedures in ACLS patients who fit the astronaut demographics and who have had more than one CAC measurement.
Update the ACLS database to include information about timing and dose of statin medications. This information will be linked with treadmill time and the clinical events from Aim 1 to develop robust, risk-prediction models.

Resources (None Listed)

Deliverables (1)

Category: Technology or Tool
Subcategory: Computational Models or Simulations

Description:
The deliverable for this task will be a risk-prediction model. Specifically, results from a review of a patients fitting the astronaut demographic will be provided, detailing clinical cardiovascular events, and this information will be combined with medication tracking information for modeling purposes.

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Health Outcomes and Decrements in Performance Due to Medical Conditions that occur in Mission, as well as Long Term Health Outcomes Due to Mission Exposures

Medical-501: We need to develop integrated exploration medical system models for the Moon and Mars.

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Adverse Health Outcomes and Decrements in Performance Due to Medical Conditions that occur in Mission, as well as Long Term Health Outcomes Due to Mission Exposures