Task Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: SR Intestinal Microflora
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. We will compare differences in degree of DNA damage, inflammation, and oxidative stress, which are all suspected to play a role in carcinogenesis in addition to cancer and lifespan.
  2. Since exposure to different radiation qualities can affect responses such as DNA damage and repair, gene expression, carcinogenesis, and longevity, we will also study effects of intestinal microbiota in response to different radiation qualities.
  3. Finally, since we have found that females are more susceptible to 1 Gy, 1 GeV iron ion-induced life-shortening, we will analyze all endpoints in both male and female mice to investigate reasons for this discrepancy.

 

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