Task Two-Hit Model of Alzheimer's Disease (Completed)
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: Two-Hit Alzheimer's
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):

Aim 1: To determine whether space radiation induces AD-relevant pathological changes in fully differentiated primary hippocampal neurons from CRN8 APP Tg mouse and 3xTg AD mouse models.

Aim 2: To determine whether space radiation induces neurodegeneration and exacerbate AD-relevant pathological/cognitive/behavioral changes in 3xTg AD mice. These proposed studies will specifically addressed many of the critical issues NASA has identified.


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