Task Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Functional Decline - Alzheimers
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Comparison of proton, silicon and iron radiation on selected neurophysiological end points in APP/PS1 tg mice will provide valuable information about the risks of space radiation-induced neurodegenerative processes. The functional endpoints will be directly correlated with expression of immunohistochemical markers of neurodegeneration, including amyloid plaque load, synaptic proteins and the presence of neuroinflammatory cytokines. This information can be directly related to risks of AD onset in human subjects.
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