Task Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Brain Proteome
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Aim 1. Identify changes in the neuroproteome that are associated with Hze-induced spatial memory impairments (HISMI) and HZE-induced Attentional Set Shifting Impairments (HIASSI).

Aim 2. Identify proteins that are present in the serum and CSF that are biomarkers of an individual rat¿s susceptibility to HISMI/HIASSI.

Aim 3. Determine the LET-dependency for HISMI and HIASSI, and whether the threshold dose is modified by prior exposure to protons, and if the underlying mechanisms of HISMI and HIASSI is constant irrespective of the LET of the Hze particle.

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