Task Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Lee)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Cardio Ox (Cardiovascular Oxidative Damage)
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

SA 1.  To determine the effects of long-duration spaceflight on measures of oxidative and inflammatory stress.

H1: Levels of inflammatory and oxidative biomarkers will be higher during long duration spaceflight, compared to pre-flight levels, and remain elevated immediately following spaceflight.

SA 2. 
To determine the effects of long-duration spaceflight on measures of arterial structure and function through R+3.

H1:
Arterial function, assessed by flow-mediated dilation, will be impaired following long duration spaceflight through R+3.  Carotid intima-medial thickness will increase in response to long duration spaceflight and will stay increased, although at a subclinical level, throughout recovery.

SA 3. 
To determine how alterations in vascular function and structure correlate with changes in circulating biomarkers of oxidative and inflammatory stress.

H1:
Statistical analysis of these biomarkers and indices of atherosclerosis risk will yield a cadre of potential candidates for predictors of vascular dysfunction and atherosclerosis risk.

SA4
: To monitor vascular status of astronauts for up to five years after the completion of their long-duration space flight mission (surveillance). 

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