Short Title:
Cardio Ox (Cardiovascular Oxidative Damage)
Responsible HRP Element:
Human Health Countermeasures
|
Collaborating Org(s):
|
| Space Radiation (SR) Element |
|
Funding Status:
Active - Currently funded and in progress
|
Procurement Mechanism(s):
|
|
Aims:
SA 1. To determine the effects of long-duration spaceflight on measures of oxidative and inflammatory stress.
H1: Levels of inflammatory and oxidative biomarkers will be higher during long duration spaceflight, compared to pre-flight levels, and remain elevated immediately following spaceflight.
SA 2. To determine the effects of long-duration spaceflight on measures of arterial structure and function through R+3.
H1: Arterial function, assessed by flow-mediated dilation, will be impaired following long duration spaceflight through R+3. Carotid intima-medial thickness will increase in response to long duration spaceflight and will stay increased, although at a subclinical level, throughout recovery.
SA 3. To determine how alterations in vascular function and structure correlate with changes in circulating biomarkers of oxidative and inflammatory stress.
H1: Statistical analysis of these biomarkers and indices of atherosclerosis risk will yield a cadre of potential candidates for predictors of vascular dysfunction and atherosclerosis risk.
SA4: To monitor vascular status of astronauts for up to five years after the completion of their long-duration space flight mission (surveillance).
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Quantify risk of vascular dysfunction and possible atherosclerosis risk
Internal Customers:
Human Health Countermeasures
External Customers:
None
Category:
Standard
Subcategory:
Update
Description:
Quantify risk of vascular dysfunction and possible atherosclerosis risk
Internal Customers:
Human Health Countermeasures
External Customers:
None