Task Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: Biomarkers for Behavioral Health
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Ground study to determine optimal methods for detecting individual vulnerabilities and resiliences to sleep loss and circadian desynchronization. Findings will help inform individualized countermeasure regimens for spaceflight. Touchpoint with Sleep

Aim 1: Perform individualized analyses and modeling of our extensive laboratory data set from inpatient studies ranging from 4-74 days including biomarkers such as sleep (EEG, actigraphy, logs); repeated measures of neurocognitive performance including attention, vigilance, motor control, and short-term memory; repeated measures of alertness (waking EEG, subjective scales); circadian phase (melatonin, cortisol, temperature); stress and activation (heart rate variability, blood pressure, catecholamines, cortisol), metabolism (lipid metabolism, glucose metabolism), immune function (cytokine and chemokine rhythms) and mood (clinical questionnaires, subjective scales) and multiple other physiological and metabolic measures.

Aim 2: Conduct a series of short 7-day inpatient studies on astronaut-aged healthy male and female volunteers to test the sensitivity and specificity of multiple biomarkers to predict inter-individual responses to sleep and circadian challenges.


Aim 3: Evaluate the feasibility and utility of implementing a standardized set of objective and subjective predictive biomarkers for neurocognitive impairment and behavioral health outcomes in Antarctica.