HRR - Task - Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

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- CVD-103
  - Cardiovascular

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Zwart, Sarah

Short Title: Radiation/Iron

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:
TBD

Integration/Unique Aspects: TBD

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
TBD-
Date is a placeholder only no info at this time

Internal Customers:
None External Customers:
None

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Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

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Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

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	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

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	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
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2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

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	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Galactic Cosmic Ray Simulator and Mitigation Project

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Multi-Model Ensemble Risk Assessment

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Space Relevant Radiation-Induced Cardiovascular Disease Risk Thresholds: Effect of Gender on the Outcome

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Countermeasures to Radiation Induced Cardiomyopathy

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Cardiovascular Disease Data Mining Phase II with Cooper Clinic

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

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Common Item(s)
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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

CVD Monitoring on Deep Space Gateway

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Rodent Lunar Stays

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	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD Integrated Flight Countermeasure Study on ISS

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD Integrated Flight Countermeasures Study for Deep Space Gateway and Lunar

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

Common Item(s)
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Venous Thromboembolism Characterization - ISS

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Maturation Task - CVD Standards based on Weightlessness to OCHMO

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Space radiation exposure and risk mediated by clonal hematopoiesis.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Integration of In-Silico and In-Vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Radiation resistance conferred by small proline rich repeat proteins (SPRRs).

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Risk Quantification Pilot with IMM for HSRB

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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Risk Approach Plans (2)

This task can be found in the following Risk Approach Plans.

Food and Nutrition Risk Approach plan
Cardiovascular Risk Approach plan

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