Task 3D Tissue Models for Study of Intercellular Signaling Stimulated by High Energy Particles (Completed)
Last Published:  07/27/17 09:48:12 AM (Central)
Short Title: 3-D Intercellular
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. We will quantify apoptosis, proliferation and differentiation, as early hallmarks of cancer, in 3D epithelial tissue models of skin, a tissues in which radiation is known to cause cancer.
  2. A novel aspect of our studies is to test the hypothesis that radiation can alter the ability of dendritic cells to participate in immune surveillance and that radiation-induced persistent oxidative stress is part of the underlying mechanism.
  3. Studies comparing radiation and bystander effects in normal, pre-cancerous and neoplastic epithelial cells will be conducted. An important component of anti-cancer processes in epithelial tissues is the immune system, including dendritic cells which are critically involved in immune surveillance against cancer.
  4. We will quantify apoptosis, proliferation and differentiation, as early hallmarks of cancer, in 3D epithelial tissue models of colon, a tissue in which radiation is known to cause cancer.
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