Task Prospective Observational Study of Ocular Health in ISS Crews (Macias) (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: Ocular Health
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Space Medicine Medical Operations (SMMO)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
The International Space Station (ISS) Ocular Health Study aims to systematically gather physiological data to characterize the Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations on crewmembers assigned to long-duration (6-12 month) ISS increments. The data collected will mirror Medical Requirements Integration Documents (MRID) requirements and testing performed during annual medical exams. The frequency of in-flight and postflight testing will be increased to more accurately assess changes that occur in the visual, vascular, and central nervous systems upon exposure to microgravity and induction of fluid shifting. Monitoring in-flight changes, in addition to postflight recovery, is the main focus of this protocol. A data sharing plan with Medical Operations will reduce redundancy of data acquisition. Preflight, in-flight and postflight measures include: tonometry, ocular ultrasound, fundoscopy, visual acuity, and optical coherence tomography (OCT); while magnetic resonance imaging (MRI), and bio-microscopy will be captured preflight and postflight exclusively. Three additional, non-MRID measures, will be collected preflight, in-flight and postflight, including blood pressure and cardiac output to assess vascular compliance, and transcranial Doppler (TCD) for Pulsatility Index (PI) to assess a surrogate measure of ICP. Data collection will begin one year prior to flight, continue in-flight approximately every 30 days, and continue through to one year postflight. In circumstances where abnormalities may persist beyond one year, postflight data will continue to be collected, but as per the MRID requirements (MedB 1.10) and Visual Impairment/Intracranial Pressure (VIIP) clinical practice guidelines.