Task Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship) (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Neurobehavioral SR
Responsible HRP Element: Behavioral Health and Performance
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

The present proposal addresses this need via the application of an animal model to determine:

  1. The long-term effects of radiation exposure on cognitive neurobehavioral function and the dopamine neurotransmitter system; and
  2. The effectiveness of flaxseed dietary supplementation to mitigate the neurobehavioral and neurochemical effects of radiation exposure.
  3. To determine DAergic and inflammatory protein levels in radiation-induced, neurobehaviorally impaired Fischer and Lewis rats and in radio-protectant-treated flaxseed rats.
  4. To assess functional changes in dopaminergic neurotransmission following head-only proton radiation using well-characterized dopamine receptor-mediated behaviors (i.e., DA agonist-induced yawning and hypothermia)
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